Saturday, March 9, 2019

Seniors Looking for Relationships


You will find the senior citizens more vibrant these days than in the previous few generations. People are not stuck up any more. Even after they cross their retirement age, they have no issues in looking for mates. They feel that a senior match would be fun that could lead to a good and lasting relationship. Many relationship experts are of an opinion that dating to form a relationship is crucial to a positive mental frame of mind, regardless of your age. Age has got nothing to do with shedding your nervousness in developing intimate relationships. Most of the time, the fear behind a senior match is all in the minds of the seniors. People above forty need not fear when they feel like dating as it can be a casual experience devoid of pressures like financial stability or fear of parents. The pressure of responsibilities or economics is less at a later age when compared to younger people because seniors would already have crossed those hurdles of settling down in life and would be earning adequately. There are times in a person’s life when he or she may feel quite lonely. This may happen due to not marrying until late in life or losing a partner as a result of death or divorce. So, mature people trying to forge a senior match are actually seeking a lasting relationship and there should be nothing embarrassing about that. People who make fun of seniors dating are being immature and stupid. Even if you are above sixty and would like to date, it is your life; there is nothing to stop you from doing that. What is wrong in looking for love when you are over sixty? Your perfect partner would be waiting somewhere online. Dating on the web, even among seniors, has grown in popularity over the last few years as revealed by a recent survey which showed that more people in their sixties have started using the online dating sites more than ever.

Monday, January 7, 2019

The First Formula One Motor Racing Driver from India


Kumar Ram Narain Karthikeyan was born on 14th January 1977 in Chennai. He did his schooling at Stanes Anglo Higher Secondary School in Coimbatore. His interest in motor sports began at a very early age. His father was a former Indian National Rally Champion, winning the South India Rally seven times. In his very first race, Narain Karthikeyan finished on the podium at Sriperumpudur in a Formula Maruti. Then, he went to the Elf Winfield Racing School in France. Narain Karthikeyan began motor racing way back in 1994 when he took part in the Formula Ford Zetec. In the same year, he became the first Indian to win the British Formula Ford Winter Series and went on to achieve a top three classification in the Portuguese Grand Prix at Estoril. Narain Karthikeyan won the Formula Asia Championship title in 1996 and became the first Indian to win an international series. In 1999, he participated in the Formula Three Championship Class where he drove in the Autosport British Formula Three Championship. He achieved five podium finishes and an additional two pole positions. He also managed three fastest laps and two lap records. He finished sixth in the Championship against a total of thirty drivers from over five countries. He also qualified sixth in the Macau Grand Prix finishing in the second leg. Narain Karthikeyan participated in the British Formula Three Championship again in 2000 and finished in fourth place. His biggest achievement in this year was winning the International Formula Three Race at Spa, Belgium. His name was being ranked in 2000 among some big shots like Michael Schumacher, David Coulthard and Ayrton Senna. Narain Karthikeyan considers Ayrton Senna as his idol. In 2001, he got a test drive opportunity with Benson and Hedges Jordan Honda EJ11. His impressive performance led him to another test drive contract at Silverstone. In 2002, he set a fastest time record in the Interlagos circuit. He claimed a pole position in the Telefonica World Series. In 2003, he entered the Super Fund World Series and finished fourth against some of the best drivers in the world. He was then offered a test drive contract by Formula One Team Minardi. Narain Karthikeyan is the first Formula One Motor racing driver from India. He has so far competed in Formula One, A1 Grand Prix and the Le Mans Series. He made his Formula One debut in 2005 with the Jordan Team. In 2013, he made a Formula One comeback after a gap of almost six years. He was also a Williams F1 test driver in 2006 and 2007. In 2007, he joined A1 Team India and raced in five weekend races. In the first race with the Team, he got the first points at Taupo, New Zealand. The team finished in fourth place in the A1 Grand Prix World Cup of Motorsports which has been their best so far. Like many other earlier F1 drivers, Narain Karthikeyan moved on to stock car racing and has driven the #60 Safe Auto Insurance Company Toyota Tundra for Wyler Racing in the 2010 NASCAR (National Association for Stock Car Auto Racing) Camping World Truck Series. In January 2011, Narain Karthikeyan announced that he has signed up to drive for the Hispania Racing Team in the Formula One Season this year. He suffered a bad mishap during the Spanish Grand prix earlier this year in the month of May when he suffered second degree burns and a prolapsed disc. It has been a testing time for him since then. But he is back in action now and is fully recovered after some fierce training sessions. Narain Karthikeyan lives in Coimbatore. He picked up the most popular driver award at NASCAR Camping World Truck Series Banquet in November 2010. He was also honoured with the Padma Shri Award in 2012.

Tuesday, September 11, 2018

The Most Powerful Tool for Analyzing your Website Data


Many website owners often wonder what their visitors would be doing once they arrive at their websites or blogs. Do they read an article or do they click on any links, navigation tabs, categories or ads? Would it not be great if the website owners could see how exactly the traffic is behaving when they visit the sites? It is not just a possibility today but a necessity and there are tools that are available to analyze the data on the website along with the behavior of the visitors. One of the most important among such tools is a website heatmap. Clickmaps Creators There are many companies who create a heatmap and clickmaps for your websites and blogs. One such company is https://www.seevolution.com/website-heatmaps. Clickmaps will track the clicks and will give results that highlight exactly where a website is excelling or falling apart in attracting the click-throughs. A heatmap can be easy to find using Google Analytics. A blog can be provided with a plugin to have access to this information. Clickmaps and Color Sliders Clickmaps use cell sizes and colors so that complex information can be displayed in a smart way. A heatmap is one of the most powerful tools for data analysis that are available for business. It is a feature that helps the website owners to visualize a presentation of multiple rows of information in a style that assigns different colors and sizes to the cells; each cell represents a row. A color slider at the bottom of the heatmap allows the user to spot all the highs and the lows quite easily. This would not be possible on a conventional bar chart to have such data represented. The result will be a clutter and it would not be practical. On a heatmap, you can have a cell assigned to each representation. The Clickmaps will be able to sort the data out by the size of the cells. Why are the Web Pages losing Searchers? Many businesses today are using clickmaps to test out new ideas on how to evolve effective landing pages. The big question is, “Why are the web pages losing searchers?” Is it because of the content which is poor and not engaging enough? The answer may be lying in a blend of certain variables that have to be potentially tested. You can begin with Clickmaps. They are a sure fire way of understanding where the website visitors or viewers are paying attention to. It allows the website owners to find out what their visitors tend to look at initially. The website owners can then try and rearrange their web pages in such a way that the most crucial content is displayed at the right places. Giving sufficient Time for a Website Heatmap to be Effective The data that is localized through a website heatmap can become useful for a web developer who will be in a position to modify the locations of where the check buttons can be placed. When you subscribe to a service provider, you will have to be clear about the number of web pages that you would like to get tracked to get the website heatmap process started. Once the data is entered, codes will be given to be inserted into the web pages so that user experience information can be gathered and preserved by the website and viewed through the heat maps. Enough time has to be provided for the tools to collect vital information. Accumulation of data for a period of three months is reasonable to make sure you have a fair idea of what is happening on your web pages before you think in terms of modifying them for achieving positive results.

The First Molecular Biologist of the World


THE FIRST MOLECULAR BIOLOGIST OF THE WORLD - THE GREATEST OF ALL PHILOSOPHERS AND SCIENTISTS OF ALL ERAS (IMAM ALI IBN E ABI TALIB as). “And at the very heart of life on earth - the proteins that control cell chemistry and the nucleic acid (DNA) that carry hereditary instructions - we find these molecules to be identical in all the plants and animals. An oak tree and I (Carl Sagan) are made of the same stuff. If you go far enough back, we have a common ancestor.” Cosmos:Carl Sagan,page 24. The above paragraph is taken form the best selling science book ‘Cosmos’ by a great science man and atheist: Carl Sagan, Director of Viking mission to mars at NASA. The main point of the above paragraph is that all living things are the same with respect to their fundamental ingredients. All the living things, from virus to human beings, have chromosomes for storing genetic information, the chromosomes are made of DNA just as a cloth or your shirt is made of fine continuous thread. And Carl Sagan’s conclusion on this phenomenon (similarity of all living things) is that it proves the common ancestry of all the living things. Now coming to another paragraph, but not from Carl Sagan's book, but from Nahjul Balagha, the paragraph is as follows, “If you tread on the path of your thinking and reach it's extremity it will not lead you anywhere except that the originator of the ant is the same as he who is the originator of the date palm, because everything has same delicacy and detail and every living being has little difference.” Nahjul Balagha: sermon.183, page 305. A thousand year old copy of Nahjul Balagha is still available at the library of Mosul, Iraq. The main point of the above paragraph of Imam Ali (a.s) is same as that of Carl Sagan's; that there is very little difference between-living-things. On analysis of the above mentioned paragraphs, it appears as if Carl Sagan and Imam Ali (a.s) are contemporaries, but everyone knows that Imam Ali (a.s) lived 1400 years before Carl Sagan. It is amazing that a man living in 700 AD in Arabia, the land of sand, ignorance, wars and scarce water should know that living things are made of the same stuff, and that there is very less difference between them. But amazingly Imam Ali (a.s) establishes a very different conclusion from the similarity among living things; that they have the same creator. Carl Sagan, a hardcore atheist and Imam Ali (a.s), a hardcore believer in God, as expected amazingly, reached the opposite conclusions about the same phenomenon (similarity of living things). A believer can accept both the conclusions and still have his faith intact, but if an atheist accepts Imam Ali’s (a.s) conclusion then he has to loose his atheism. DNA was discovered in 1950, and we know that all living things from virus, bacteria, and plants to human beings are made of DNA. So it is very correct to say that living things have little difference among them. At this stage the saying of the PROPHET (Pbuh) of Islam: ''I am the city of knowledge and Ali (a.s) is It’s gate, is realized in its greatness. ALL THE PRAISES ARE DUE TO ALLAH.

A cricketer who has left his stamp on the game


Sachin Ramesh Tendulkar was born in Bombay on 24th April 1973. He began his cricket career at Sharadashram Vidyamandir High School in Bombay under the coaching of Ramakant Achrekar. When he was 15 years and 232 days old, Sachin Tendulkar scored an unbeaten century in his debut first class match for Bombay against Gujarat on 11th December 1988, making him the youngest player to score a century on first class debut. He made his international debut for India, playing his first test match at 16 years 205 days, making him the third youngest player in the history of cricket to make a debut behind Hasan Raza (14 years 227 days) and Mushtaq Mohammad (15 years 124 days). He got his debut test century in England, making him then as the second youngest cricketer in history at 17 years 107 days behind Mushtaq Mohammad of Pakistan who made his century against India in 1961 at Delhi when he was 17 years 78 days old. Mohammad Ashraful of Bangladesh went on to become the youngest test centurion against Sri Lanka at Colombo in 2001 when he was 17 years 61 days old. Sachin Tendulkar, today, holds most if not all of the records that a batsman could endeavour to break. He has the highest number of appearances in test cricket as well as one day internationals. He has the highest number of test centuries (51), highest number of one day centuries (48), highest number of runs scored ever in tests (14692), highest number of runs scored ever in one day internationals (18111) and the highest individual score in one day internationals (200 not out). As far as Indian cricket representation goes, Sachin Tendulkar has contributed the greatest.

The Flying Sikh who has become a living Legend in India


Milkha Singh was born on 17th October 1935 in Lyallpur which has now become Faisalabad in Pakistan. He was not even twelve years old when his parents were killed right in front of his own eyes during the partition riots in Pakistan. He was heartbroken and escaped, literally running for his life, crossing the border by hanging on to the under carriage of a train that was bound for Delhi. The train was packed with refugees that were escaping to India. Once he reached Delhi, he turned to the army for his bread and butter. The Services were responsible for giving him a life support system. His Commanding Officer saw his potential as an athlete and encouraged him to take up athletics on a full time basis. The Services nurtured his dream. He had a dream and an obsession for running in track events that dominated Asian athletics to such an extent that he was respected in Manila and Tokyo during his important years on the track as a `Flying Sikh’. It is because of his determination that he showed in these early years that made the sport of athletics as his salvation and turned him into a living legend of Indian sport. During his career, he represented India in two Asian Games, two Commonwealth Games and three Olympics. He came into the limelight at the National Games in Patiala in 1956. Then he went on in the subsequent years to set a record in the 200 metres as well as the 400 metres races at Cuttack. Milkha Singh made his Olympic debut at Melbourne in 1956. It was an uneventful participation for him as he did not make a mark in any event but learnt much from the advice of an American Charles Jenkins who won the 400 metres event there. This turned out to be the turning point in Milkha Singh’s career. He trained so violently at times that he would end up vomiting blood. In the 1958 Asiad at Tokyo, he beat Pakistan’s Abdul Khan in the 200 metres race and also won the 400 metres race that became his favourite event in the future. He became a celebrity in the Asian sporting circle. In the same year at the Commonwealth Games at Cardiff that were known as the Empire Games then, he won the 400 metres race in 46.6 seconds beating the South African, Malcolm Spence. He peaked well for the Rome Olympics in 1960. He qualified for the finals. Everyone was expecting him to get a medal but the final round was tough with the best qualifiers from the world and he was pipped at the post by the same South African Malcolm Spence by a fraction of 0.01 second to come fourth even though he finished at a record 45.7 seconds from Indian standards. An Olympic medal eluded him. He went on to win the 400 metre events gold at Manila and Jakarta in the later years. Throughout India’s entire sporting history, there was not a single person who could dominate in athletics on an international level. India does not have much of a tradition in the field of sports like men’s track and field events. It is very hard to swallow the fact that a nation of over a billion people could not create heroes in track and field events in the Olympics. Yet, Milkha Singh was that first lone athlete to reach an Olympics final and almost picked up a bronze medal for India in Rome. His track record speaks highly of him. He has won 77 of the 80 races he ran during his career. After Tenzing Norgay Sherpa, he is perhaps the greatest sportsman for India. He was awarded the Padma Shri in 1958. He has become Director of Sports in the Punjab Government. His son, Jeev Milkha Singh, has kept his father’s head high by becoming the first Indian golfer to become a member of the European Tour.

Wednesday, August 22, 2018

Peptic Ulcer Drugs Classification Therapeutic Utility


Peptic ulcer disease (PUD) occurs with a break in the lining of the stomach, first part of the small intestine or occasionally the lower oesophagus. Common causes include the bacteria, Helicobacter Pylori and non-steroidal anti-inflammatory drugs (NSAIDs). Classification of PUD 1. Esophagus 2. Stomach 3.Ulcers 4.Duodenum 5.Mucosa 6.Submucosa 7.Muscle Differential Diagnosis • Gastritis • Stomach cancer • Pancreatitis • Hepatic congestion • Cholecystitis • Inferior myocardial infarction Classify the drugs used in treatment of peptic ulcer For the treatment of peptic ulcers, the main objective of pharmacotherapy is to eradicate Helicobacter Pylori infection and to reduce morbidity. This is to prevent complications in patients with peptic ulcers. Acid suppression is the general pharmacologic principle of medical management when treating acute bleeding from peptic ulcers by using Histamine II receptor antagonists (H2RAs) and Proton Pump Inhibitors (PPIs). Both these classes are available in oral and intravenous preparations. Discontinuation of NSAIDs is necessary if it is clinically possible. For those patients who have to continue with their NASAIDs, the maintenance of PPI is always recommended so that recurrences are prevented even after the eradication of Helicobacter Pylori. Explain their mechanism of action and their therapeutic utility The recommended primary therapy for treatment of peptic ulcers and helicobacter pylori infection is the proton pump inhibitor (PPI). It is combined with antacids and an anesthetic like viscous lidocaine or an antispasmodic may also be used as a symptomatic therapy. If the helicobacter pylori eradication is not achieved despite repeat treatment, then anti-secretory therapy is recommended. The patients are possibly suffering with the Zollinger-Ellison Syndrome as a secondary cause of duodenal ulcer. This is a disorder in which severe peptic ulceration is found due to edema or hyperplasia of islet of pancrease that secrete gastrin resulting in hyperchlorhydria. Classification of PPIs:- • Omeprazole (Prilosec) – It decreases gastric acid secretion by inhibiting the parietal cell H+/K+ ATP pump. It will decrease the incidence of NSAID-induced peptic ulcers and it can be used to help prevent peptic ulcers in long term NSAID users at high risk. Omeprazole and Domperidone Omeprazole and Domperidone contain a proton pump inhibitor and anti-dopaminergic agent, prescribed for ulcers, indigestion and acid stomach. Same trade names. • Lansoprazole (Prevacid) – It decreases gastric acid secretion by inhibiting the parietal cell H+/K+ ATP pump. It is given with clarithromycin and amoxicillin or metronidazole if the patient is allergic to penicillin. • Rabeprazole (Aciphex) – It decreases gastric acid by inhibiting the parietal cell H+/K+ ATP pump. It is used for a short term treatment of two months and elief of symptomatic erosive gastroesophageal reflux disease. If patients are not healed in this time, then an additional treatment of two months is prescribed. • Esomeprazole (Nexium) – This is an S-isomer of Omeprazole. It inhibits gastric acid secretion by inhibiting the H+/K+-ATPase enzyme system at the secretory surface of gastric parietal cells. It is used in severe cases. • Pantoprazole (Protonix)- It suppresses gastric acid secretion by inhibiting H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cells. Pantoprazole Pantoprazole is a proton-pump inhibitor, prescribed for gastro-oesophageal reflux disease (GERD), ulcers, Zollinger-Ellison Syndrome, and erosive oesophagitis. It decreases the amount of acid made in the stomach. Trade Names - Pandom | Acidwel | Azpan - DM | Histamine II Blocker Treatment Classification:- • Cimetidine (Tagamet) – It can be used as primary therapy to heal peptic ulcers that are not associated with helicobacter pylori infection. The duration of treatment is two months. • Famotidine (Pepcid) – This inhibits histamine at H2 receptor of gastric parietal cells effectively resulting in reduced gastric acid secretion, gastric volume and hydrogen ion concentrations. Famotidine is a histamine (H2-receptor antagonist), prescribed for ulcer. Trade Names - Famoflam (20 mg) | Acidosh (20 mg) | Blocacid (20 mg) | • • Nizatidine (Axid) – This inhibits histamine at H2 receptor of gastric parietal cells resulting in reduced gastric acid secretion, gastric volume and hydrogen ion concentrations. • Ranitidine (Zantac) – This inhibits histamine stimulation of the H2 receptor in gastric parietal cells and reduces gastric acid secretion, gastric volume and hydrogen ion concentrations. Ranitidine and famotidine, which are both H2 receptor antagonists, provide relief of peptic ulcers, heartburn and indigestion. They decrease the amount of acid in the stomach helping with healing of ulcers. When Helicobacter Pylori infection is present, the most effective treatments are combinations of two antibiotics (e.g. clarithromycin, amoxicillin, tetracycline, metronidazole) and a proton-pump inhibitor (PPI), sometimes together with a bismuth compound. This is acid reducing medication. Ranitidine is an antacid, anti-reflux agent and anti-ulcerant, prescribed for peptic ulcer. Trade Names - Giran | Intac | Acispas | Ani -Spa Younger patients with ulcer-like symptoms are often treated with antacids or H2 antagonists before endoscopy is undertaken. People who are taking non-steroidal anti-inflammatories (NSAIDs) may also be prescribed a prostaglandin analogue (misoprostol) in order to help prevent peptic ulcers. Classification of Drugs for Peptic Ulcers Aluminum Hydroxide and Magnesium Hydroxide Aluminum Hydroxide and Magnesium Hydroxide contains antacids, prescribed for preventing ulcers, heartburn relief, acid indigestion and stomach upsets. Aluminum Hydroxide and Magnesium Hydroxide neutralizes acid in the stomach. Trade Names - Aludrox | Dizicum | Glycopyrrolate Glycopyrrolate is a muscarinic anticholinergic agent, prescribed for peptic ulcer in combination with other medicines and also used in anesthesia as preoperative medication. It reduces acid and saliva secretions. Trade Names - Camolate (0.2 mg) | Glyco P (0.2 mg) | Vagolate (0.2 mg) | Lafutidine Lafutidine is an antacid, prescribed for ulcer. Trade Names - Laciloc (10mg) | Lafaxid (10mg) | Lafutax (10 mg) | Mepenzolate Mepenzolate is an anti-muscarinic agent, prescribed for the treatment of peptic ulcer combined with other medication. It decreases acid secretion in the stomach and control intestinal spasms. Trade Names – A Kare and Mifenac. Misoprostol Misoprostol is a synthetic prostaglandin; prescribed for ulcer, labor induction, induced abortion, miscarriage, postpartum hemorrhage (blood loss during birth) and other gynecological uses. Trade Names – Misonac and Safeguard Oxyphenonium Oxyphenonium is an anti-muscarinic agent, prescribed for peptic ulcer and it prevents muscle spasm in the gastrointestinal tract. Trade Names - Alupromate D | Oxyphenonium Bromide | Ulpane | Pirenzepine Pirenzepine is an antacid, prescribed for peptic ulcer. Trade Name – Same. Propantheline Propantheline is an anti-muscarinic agent, prescribed for peptic ulcer, and urinary incontinence. Trade Names - Pepler | Probanthine | Sere Banthine | Ulsedin |